There are neurons in your skin that are wired for one purpose and one purpose only: to sense itchy things. These neurons are separate from the ones that detect pain, and yet, chemical-induced itch is often accompanied by mild pain such as burning and stinging sensations. But when it comes to sending signals toward your brain through your spinal cord, itch and mild pain can go through the same set of spinal cord neurons, according to new research reported in Neuron. This finding explains why pain often accompanies intense chemical-induced itch.
“To our surprise, we found the spinal cord neurons receiving the peripheral pain and itch inputs are not separate. They can receive signals from itch fibres and also pain fibres,” said author Xinzhong Dong, a neuroscientist at Johns Hopkins University. These neurons, called the GRP neurons, are a way station for pain and itch signals on their way to the brain.
However, GRP neurons are not passive conduits, the researchers found. “When we eliminate this population of neurons in mice, the itch response is reduced. They scratch less,” said Shuohao Sun, a graduate student at Hopkins. “But at the same time, the pain response is actually increased.”
Mice without GRP neurons spent more time rubbing and licking to alleviate their pain, induced, for example, by exposing their tails to hot water. Further experiments that tracked electrical signalling through the neurons corroborated the result. Even though the GRP neurons seemed to be forwarding mild pain signals to the next neural relay station, they also seemed to mitigate intense pain signals.
“It might sound counterintuitive, but we suggest that this small group of cells actually functions like a braking system for pain,” said Sun. “This brake is not always triggered by the painful stimuli; it’s only triggered by the strong pain stimuli. When the brake is on, the signal doesn’t go through. But when you have a weak pain signal, it doesn’t trigger the brake and the signal can go through.” The researchers have named this hypothesis “the leaky gate” model.
When the mice’s GRP neurons have been destroyed, the brake lines have essentially been cut, resulting in an uncontrolled cascade of pain. The braking system may be a way for animals to detect mild pains without becoming overwhelmed by the pain, the researchers say. At the same time, GRP neurons are not the only group of spinal cord neurons that receive and forward pain signals toward the brain, and the brain itself plays a central role in translating signals from peripheral neurons into experienced sensation. Questions remain about what happens to the signals from GRP neurons after they’re transported up the spinal cord, but the authors say a better understanding of the pain and itch signals’ journey to the brain may eventually lead to new treatment options.
Source: Cell Press
Reference: Sun and Xu et al. Leaky gate model: intensity-dependent coding of pain and itch in the spinal cord. Neuron, 2017
doi: 10.1016/j.neuron.2017.01.012
